Effect of mild cognitive impairment on the patterns of neural activity in early Parkinson's disease.
Identifieur interne : 000A76 ( Main/Exploration ); précédent : 000A75; suivant : 000A77Effect of mild cognitive impairment on the patterns of neural activity in early Parkinson's disease.
Auteurs : Atsuko Nagano-Saito [Canada] ; Claudine Habak ; Beatriz Mejía-Constaín ; Clotilde Degroot ; Laura Monetta ; Thomas Jubault ; Christophe Bedetti ; Anne-Louise Lafontaine ; Sylvain Chouinard ; Valérie Soland ; Alain Ptito ; Antonio P. Strafella ; Oury MonchiSource :
- Neurobiology of aging [ 1558-1497 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Cognition, Cognitive Dysfunction (complications), Cognitive Dysfunction (diagnosis), Cognitive Dysfunction (physiopathology), Cognitive Dysfunction (psychology), Corpus Striatum (physiopathology), Executive Function, Female, Hippocampus (physiopathology), Humans, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Prefrontal Cortex (physiopathology).
- MESH :
- complications : Cognitive Dysfunction, Parkinson Disease.
- diagnosis : Cognitive Dysfunction, Parkinson Disease.
- physiopathology : Cognitive Dysfunction, Corpus Striatum, Hippocampus, Parkinson Disease, Prefrontal Cortex.
- psychology : Cognitive Dysfunction, Parkinson Disease.
- Aged, Cognition, Executive Function, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neuropsychological Tests.
Abstract
We have previously observed decreased activation of corticostriatal loops involved in planning (cognitive loop) and execution (motor loop) of a set shift in patients with early Parkinson's disease (PD) compared with control subjects. Here, we aimed to assess whether cognitive impairment in PD could drive these differences. Nondemented patients underwent a comprehensive neuropsychological evaluation and participated in our Wisconsin Card Sorting task functional magnetic resonance imaging protocol. Patients were separated into 2 groups according to the presence of mild cognitive impairment (MCI). Patients with MCI displayed reduced activity in the cognitive corticostriatal loop, which includes the caudate nucleus and prefrontal cortex while planning a set shift, whereas non-MCI patients exhibited activation patterns similar to those of healthy participants from our previous studies. Furthermore, reduced activation was observed in the premotor cortex of the MCI patients. Finally, hippocampal activity, correlated with individual memory scores, suggesting a compensatory mechanism in patients with preserved memory. These results suggest that the presence of MCI in PD affects activity in the prefrontal cortex and caudate nucleus as well as motor-related regions.
DOI: 10.1016/j.neurobiolaging.2013.06.025
PubMed: 23932879
Affiliations:
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Here, we aimed to assess whether cognitive impairment in PD could drive these differences. Nondemented patients underwent a comprehensive neuropsychological evaluation and participated in our Wisconsin Card Sorting task functional magnetic resonance imaging protocol. Patients were separated into 2 groups according to the presence of mild cognitive impairment (MCI). Patients with MCI displayed reduced activity in the cognitive corticostriatal loop, which includes the caudate nucleus and prefrontal cortex while planning a set shift, whereas non-MCI patients exhibited activation patterns similar to those of healthy participants from our previous studies. Furthermore, reduced activation was observed in the premotor cortex of the MCI patients. Finally, hippocampal activity, correlated with individual memory scores, suggesting a compensatory mechanism in patients with preserved memory. These results suggest that the presence of MCI in PD affects activity in the prefrontal cortex and caudate nucleus as well as motor-related regions.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bedetti, Christophe" sort="Bedetti, Christophe" uniqKey="Bedetti C" first="Christophe" last="Bedetti">Christophe Bedetti</name><name sortKey="Chouinard, Sylvain" sort="Chouinard, Sylvain" uniqKey="Chouinard S" first="Sylvain" last="Chouinard">Sylvain Chouinard</name><name sortKey="Degroot, Clotilde" sort="Degroot, Clotilde" uniqKey="Degroot C" first="Clotilde" last="Degroot">Clotilde Degroot</name><name sortKey="Habak, Claudine" sort="Habak, Claudine" uniqKey="Habak C" first="Claudine" last="Habak">Claudine Habak</name><name sortKey="Jubault, Thomas" sort="Jubault, Thomas" uniqKey="Jubault T" first="Thomas" last="Jubault">Thomas Jubault</name><name sortKey="Lafontaine, Anne Louise" sort="Lafontaine, Anne Louise" uniqKey="Lafontaine A" first="Anne-Louise" last="Lafontaine">Anne-Louise Lafontaine</name><name sortKey="Mejia Constain, Beatriz" sort="Mejia Constain, Beatriz" uniqKey="Mejia Constain B" first="Beatriz" last="Mejía-Constaín">Beatriz Mejía-Constaín</name><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><name sortKey="Monetta, Laura" sort="Monetta, Laura" uniqKey="Monetta L" first="Laura" last="Monetta">Laura Monetta</name><name sortKey="Ptito, Alain" sort="Ptito, Alain" uniqKey="Ptito A" first="Alain" last="Ptito">Alain Ptito</name><name sortKey="Soland, Valerie" sort="Soland, Valerie" uniqKey="Soland V" first="Valérie" last="Soland">Valérie Soland</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name></noCountry><country name="Canada"><noRegion><name sortKey="Nagano Saito, Atsuko" sort="Nagano Saito, Atsuko" uniqKey="Nagano Saito A" first="Atsuko" last="Nagano-Saito">Atsuko Nagano-Saito</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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